A blood sample may also be taken from a vein in the pancreas for testing.
Sometimes, surgery is needed to diagnose and treat this condition. During this procedure, the surgeon examines the pancreas by hand and with ultrasound.
Treatment depends on the type of tumor and if it is cancerous.
Cancerous tumors can grow quickly and spread to other organs. They may not be treatable. Tumors are usually removed with surgery, if possible.
If cancer cells spread to the liver, a part of the liver may also be removed, if possible. If the cancer is widespread, chemotherapy may be used to try and shrink the tumors.
If the abnormal production of hormones is causing symptoms, you may receive medications to counteract their effects. For example, with gastrinomas, the overproduction of gastrin leads to too much acid in the stomach. Medications that block stomach acid release can reduce symptoms.
You may be cured if the tumors are surgically removed before they have spread to other organs. If tumors are cancerous, chemotherapy may be used, but it usually cannot cure patients.
Life-threatening problems (such as very low blood sugar) can occur due to excess hormone production, or if the cancer spreads throughout the body.
Hormone crises (if the tumor releases certain types of hormones)
Severe low blood sugar (from insulinomas)
Severe ulcers in the stomach and small intestine (from gastrinomas)
Spread of the tumor to the liver
When to Contact a Medical Professional
Call your health care provider if you develop symptoms of these tumors, especially if you have a family history of MEN I.
There is no known prevention for these tumors.
Mauro LA, Herman JM, Jaffee EM, Laheru DA. Carcinoma of the pancreas. In: Niederhuber JE, Armitage JO, Doroshow JH, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2013:chap 81.
National Cancer Institute: PDQ Pancreatic Cancer Treatment. Bethesda, Md: National Cancer Institute. Date last modified: Feb. 21, 2014. Available at: http://cancer.gov/cancertopics/pdq/treatment/pancreatic/HealthProfessional. Accessed: March 23, 2014.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Pancreatic cancer. Version 1.2014. Available at: http://www.nccn.org/professionals/physician_gls/pdf/pancreatic.pdf. Accessed: March 23, 2014.
Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.