Secondary peritonitis is an inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs.
Secondary means it is due to another condition, most commonly the spread of an infection from the digestive tract.
Causes, incidence, and risk factors
Secondary peritonitis has several major causes. Bacteria may enter the peritoneum through a hole (perforation) in the gastrointestinal tract. Such a hole may be caused by a ruptured appendix, stomach ulcer, perforated colon, or injury, such as a gunshot or knife wound.
Secondary peritonitis can also occur when bile or chemicals released by the pancreas (pancreatic enzymes) leak into the lining of the abdominal cavity.
Foreign contaminants can also cause secondary peritonitis if they get into the peritoneal cavity. This can occur during use of peritoneal dialysis catheters or feeding tubes.
Inflammation of the peritoneal cavity caused by bacteria can result in infection of the bloodstream (sepsis) and severe illness.
Surgery is usually necessary to remove sources of infection such as an infected bowel, inflamed appendix, or abscess.
General treatment includes:
Fluids through a vein (IV)
Tube through the nose into the stomach or intestine (nasogastric or NG tube)
The outcome depends on the underlying cause, the duration of symptoms before treatment, and the general health of the patient. Outcomes can range from complete recovery to overwhelming infection and death, depending on these factors.
Gangrene (dead) bowel
Intraperitoneal adhesions ( (a potential cause of future bowel blockage)
Call your health care provider if you develop symptoms of peritonitis. This is a serious condition that typically requires emergency medical treatment.
Turnage RH, Richardson KA, Li BD, McDonald JC. Abdominal wall, umbilicus, peritoneum, mesenteries, omentum, and retroperitoneum. In: Townsend CM, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 18th ed. St. Louis, Mo: WB Saunders; 2008:chap 43.
Wyers SG, Matthews JB. Surgical peritonitis and other diseases of the peritoneum, mesentery, omentum, and diaphragm. In: Feldman M, FriedmanLS, Brandt LJ, eds. Sleisenger & Fordtran’s Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 37.
Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.